AChRs 73, 74, 81, 83, 85, 87, 98
ADAM proteases 64
adherens 6, 28, 37, 42
adherens
catenins 6
junctions 40, 42
adherins
E-cadherin 6, 40, 42
ankyrins 46
antigen presentation 10, 110, 121, 122, 180
antigen presenting cells 10, 121, 122, 180
antigen recognition 120, 125
AP2a 20, 23
AP2α 18, 30
autoimmune neuropathies 119
axonal fasciculation 57, 58
BAPTA 88
BFABP 15, 20, 23, 25
blood–nerve barrier 104, 116, 118, 164, 178
BMP2 21, 23, 26, 32
cadherin 19 20
Cajal-Bands 70
cAMP 19, 35, 85, 105, 106, 114, 115, 117
Caspr 37, 49, 50, 52, 53, 129, 137, 145
Caspr2 37, 49, 50, 52
CD4 T cells 103, 110, 121, 122, 167, 180
CD4+ T-cells 103
CD8 T cells 110, 111, 121, 178, 180
cell-mediated immunity 104
Charcot–Marie–Tooth
CMT disease 11, 12
chemokine receptors 101, 102
chemokines 10, 101, 116, 117, 121, 179
chronic inflammatory demyelinating polyneuropathy 12, 102
chronic inflammatory demyelinating polyradiculoneuropathy 122, 159
Claudin 42
CNS
astrocytes 9, 14, 15, 31, 72, 73, 84, 86, 99, 100, 106, 107, 150
oligodendrocytes 9, 14, 44, 59, 113, 149, 150
collagen IV 56
collagen V 57
congenital muscular dystrophy 61
co-stimulatory molecules
BB-1 122, 180
Cre/LoxP 69, 70
Cx29 37, 40, 44, 50, 51
Cx32 40, 50, 130, 145–9
CXCR4 117
cytokine receptor
TNF-R 111
cytokines 9, 10, 100–5, 107, 109–15, 117, 118, 121, 123–5, 160, 179
IFN-γ 110–12, 114, 116, 122
IL-1 104, 105, 109, 111, 112, 114, 123
IL-1β 111
IL-6 104, 112, 114, 123
lymphotoxin 101, 113
TGF 85, 86, 104, 106, 108, 109, 112, 113, 123, 125
TGF-β 111
TGF-β1 111, 114
TNF 103–6, 110, 113, 117, 121, 123–5, 179
TNF-α 111, 112, 114–16
tumor necrosis factor 101, 121, 125, 179
demyelination 12, 41, 46, 53, 54, 103–5, 107, 116, 119, 120, 131, 135, 140, 142, 144, 145, 153, 160, 162, 163, 169–75, 177, 180, 181
dendritic cells 110, 120, 121, 180
desert hedgehog 31
Duchenne muscular dystrophy 94
dystroglycan 37, 48, 55, 58, 63–6, 69, 70, 152
dystrophic mice 69, 70
EAN 103, 104, 116, 119, 160, 169, 172, 178–81
endoneurial fibroblasts 14, 29–31, 55
endostatin 56
endothelins 30
ErbB 84, 85, 95
ErbB2 26, 28, 31, 33
extracellular matrix 9, 22, 23, 29, 48, 55–8, 64, 71, 73, 76, 89, 93, 116, 152
basal lamina 4, 21, 30, 34, 39, 41, 58–63, 65, 68, 76, 93, 94, 97, 152, 160, 175, 179
fibrin 59, 60
metalloproteinases 104, 179
nidogen 63
F-actin 6, 75
FGF 23, 34, 57
fibronectin 59, 60
functional genomics 6
galactocerebroside 21, 39, 42, 49, 79, 103, 104, 119, 163, 169, 181, 182
galactoplipids 106, 114
gangliosides 38, 52, 53, 76, 91, 120, 155, 167, 168, 172, 181
gap junctions 37, 44, 145, 147–9
GFAP 20, 23, 26, 79, 91, 95, 105
gliogenesis 13, 23, 25, 26
glycoproteins
tenascins 58
glypican 57
Guillain–Barré Syndrome 12
heparan sulphate proteoglycans 48
ICAM-1 111, 179
IGF2 30
IL-1R 112
inner mesaxon 47, 51, 52, 130, 137
integrins
α5β1 integrin 60
LFA-1α 111
LFA-1β 111
integrin linked kinase 69
internodal region 51
intracellular calcium 87
intraperiod lines 39
JNK 34
juxtaparanode 49, 129
Krox-20 19, 21, 35, 38
L1 21, 23, 111, 115
laminin receptors 39, 56, 61, 63–6, 68, 69, 71
laminin α4-null mice 68
LIF 30
lipopolysaccharide 120, 125
Louis-Antoine Ranvier 76
LPS 120, 121, 125
macrophage chemoattractant protein 116
macrophage inflammatory protein-1 alpha 116
macrophages 103, 119, 144, 180
MAG 38, 40, 51, 52, 59, 66, 79, 111, 129, 181, 183
MCP-1 116
membrane attack complexes 91, 163
metalloprotease 56
MHC class I molecules 110, 111, 121
MHC class II molecules 4, 110, 121, 125, 180
microvilli 37, 48, 58, 64, 66, 68, 70
Miller–Fisher syndrome 76, 91
miniature endplate potentials 78
MIP-1α 116
molecular mimicry 119, 120, 168
myelin lamellae 3, 24, 28, 37–9, 41, 43, 44, 48–50, 53, 66, 70, 119, 125, 129, 137, 144, 147, 153, 160, 161, 163, 170, 174
myelin-related proteins
MBP 21, 37, 40, 42, 66, 105, 122, 129, 137, 138
P0 15, 20, 21, 23, 26, 32, 37, 39–42, 79, 103, 105, 111, 119, 144, 169, 170, 172, 180, 181, 183
P2 103, 119, 122, 169, 172, 180
PLP 21, 23
PMP22 21, 23, 37, 39–42, 127–9, 131–6, 138, 140, 147, 148, 151, 169, 180
myelin-forming Schwann cells 5
myelination
radial sorting 19, 33, 68
Nav 37, 38, 44, 46, 48, 49, 54
Nav channels 45–9
N-cadherin 111
N-CAM 21, 57
neural crest cells 13, 15, 17, 20–2, 25–9, 108
neural crest stem cells 14, 15
neuregulin-1 21, 38
neuroglycan C 57
neuromuscular junctions 50, 73–5, 77–84, 86, 88–93, 95, 97–9
neuroproteomics 6
neurotrophic factors 9
NFkB 19, 35
neurotrophic factors
BDNF 9, 11, 19, 33, 36, 85
NGF 10, 11, 34, 95, 109, 114
NT-3 9
NGFRp75 105, 114, 115
nodes of Ranvier 44, 55, 58, 59, 61, 63, 66, 68, 70, 129, 144, 163, 167
non-myelin forming Schwann cells 7, 68
Notch 18, 23, 25, 30, 35
Nr-CAM 37, 38, 47, 48
NRG1 18, 21, 23, 25–8, 31, 33–6, 82, 85, 95
NT3 19, 23, 30, 33, 35, 85
NTR 18, 21, 34
p38MAP kinases 33
paranodal loops 48, 130, 147, 149, 153, 182
Pax-3 19, 35
PDGF-BB 30
perisynaptic Schwann cells 4, 8, 14, 72, 74, 79, 168
PINCH 65, 69
presentation of antigens 110, 119 See also antigen presentation
presynaptic nerve terminal 8, 72, 75
proteoglycans 57
PSC processess 81, 94
radial sorting 33, 61, 68, 128
RANTES 116
Remak bundles 3, 7
remyelination 46, 60, 114, 116, 144, 174
repressor proteins 36
S100 20, 23, 24, 75, 79, 91
saltatory conduction 37, 38, 44, 129, 132
satellite cells 4, 7
Schmidt–Lanterman incisures 6, 149
Schwann cell differentiation 9, 55, 105, 108, 114, 130
Schwann cell microvilli 45, 70
Schwann cell migration 19, 33, 57–60, 106
Schwann cell precursors 13–15, 17, 18, 20–2, 26–32, 66, 79, 85, 105, 108, 128
Schwann cells junctions 88
Schwannopathy 104
septate-like junctions 49
small myelin protein 32
sodium channels 59, 70, 91, 137
Sox-10 18, 20, 23, 25, 31, 35
splotch 80
β1integrin 33
stem cell factor 103
stromal cell derived factor-1 117
sulphatide 21, 39, 42, 49
synapse
tripartite synapse 8, 73
synaptic growth 81–5, 99
synaptic remodeling 78, 93
synaptogenesis 81, 82, 84–6, 99
syndecan 57, 58
TAG-1 37, 50, 52, 57
TGFβ 34
Theodor Schwann 1, 2, 76
Toll-like receptors 120, 125
TLR-2 120
TLR-4 120
Trembler J mice 46, 53
tripartite synapse 72
unmyelinated fibres 6, 177
vitronectin 59
voltage-gated potassium channels 46
Wallerian degeneration 59, 89, 104, 107, 109, 164